Publications

Atypical peripheral actin band formation via overactivation of RhoA and nonmuscle myosin II in mitofusin 2-deficient cells.

Wang Y, Troughton LD, Xu F, Chatterjee A, Ding C, Zhao H, Cifuentes LP, Wagner RB, Wang T, Tan S, Chen J, Li L, Umulis D, Kuang S, Suter DM, Yuan C, Chan D, Huang F, Oakes PW, Deng Q.

Elife. 2023 Sep 19;12:e88828. doi: 10.7554/eLife.88828.

PMID: 37724949 

Engineered hematopoietic and immune cells derived from human pluripotent stem cells.

Chang Y, Hummel SN, Jung J, Jin G, Deng Q, Bao X.

Exp Hematol. 2023 Aug 22:S0301-472X(23)01674-0. doi: 10.1016/j.exphem.2023.08.006. Online ahead of print.

PMID: 37611730

Method for Visualization of Emergency Granulopoiesis in the Zebrafish Embryo.

Syahirah R, Beckman J, Malik H, Hsu AY, Deng Q.

Zebrafish. 2023 Jun 12. doi: 10.1089/zeb.2023.0014. Online ahead of print.

PMID: 37306974

Engineered anti-prostate cancer CAR-neutrophils from human pluripotent stem cells.

Harris JD, Chang Y, Syahirah R, Lian XL, Deng Q, Bao X.

J Immunol Regen Med. 2023 May;20:100074. doi: 10.1016/j.regen.2023.100074. Epub 2023 Apr 1.

PMID: 37089616

CAR-neutrophil mediated delivery of tumor-microenvironment responsive nanodrugs for glioblastoma chemo-immunotherapy.

Chang Y, Cai X, Syahirah R, Yao Y, Xu Y, Jin G, Bhute VJ, Torregrosa-Allen S, Elzey BD, Won YY, Deng Q, Lian XL, Wang X, Eniola-Adefeso O, Bao X.

Nat Commun. 2023 Apr 20;14(1):2266. doi: 10.1038/s41467-023-37872-4.

PMID: 37080958

Chemically defined generation of human definitive hematopoietic stem and progenitor cells.

Jung J, Chang Y, Jin G, Deng Q, Lian XL, Bao X.

STAR Protoc. 2022 Dec 16;4(1):101953. doi: 10.1016/j.xpro.2022.101953. Online ahead of print.

PMID: 36527716 

Macrophages and neutrophils are necessary for ER stress-induced β cell loss.

Yang B, Yang L, Wang Y, Maddison LA, Tang Z, Haigh S, Gong Y, Zhang Y, Covington BA, Bosma KJ, Tong X, Page-McCaw P, Gannon M, Deng Q, Chen W.

Cell Rep. 2022 Aug 23;40(8):111255. doi: 10.1016/j.celrep.2022.111255.

PMID: 36001973 

Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy.

Chang Y, Syahirah R, Wang X, Jin G, Torregrosa-Allen S, Elzey BD, Hummel SN, Wang T, Li C, Lian X, Deng Q, Broxmeyer HE, Bao X.

Cell Rep. 2022 Jul 19;40(3):111128. doi: 10.1016/j.celrep.2022.111128.

PMID: 35858579 

Chemically-defined generation of human hemogenic endothelium and definitive hematopoietic progenitor cells.

Chang Y, Syahirah R, Oprescu SN, Wang X, Jung J, Cooper SH, Torregrosa-Allen S, Elzey BD, Hsu AY, Randolph LN, Sun Y, Kuang S, Broxmeyer HE, Deng Q, Lian X, Bao X.

Biomaterials. 2022 Jun;285:121569. doi: 10.1016/j.biomaterials.2022.121569. Epub 2022 May 6.

PMID: 35567999 

Rora Regulates Neutrophil Migration and Activation in Zebrafish.

Hsu AY, Wang T, Syahirah R, Liu S, Li K, Zhang W, Wang J, Cao Z, Tian S, Matosevic S, Staiger CJ, Wan J, Deng Q.

Front Immunol. 2022 Mar 4;13:756034. doi: 10.3389/fimmu.2022.756034. eCollection 2022.

PMID: 35309302 

A curious case of cyclin-dependent kinases in neutrophils.

Syahirah R, Hsu AY, Deng Q.

J Leukoc Biol. 2022 May;111(5):1057-1068. doi: 10.1002/JLB.2RU1021-573R. Epub 2022 Feb 21.

PMID: 35188696 

Mitofusin-2 regulates leukocyte adhesion and β2 integrin activation.

Liu W, Hsu AY, Wang Y, Lin T, Sun H, Pachter JS, Groisman A, Imperioli M, Yungher FW, Hu L, Wang P, Deng Q, Fan Z.

J Leukoc Biol. 2022 Apr;111(4):771-791. doi: 10.1002/JLB.1A0720-471R. Epub 2021 Sep 8.

PMID: 34494308 

 Reduced electron transport chain complex I protein abundance and function in Mfn2-deficient myogenic progenitors lead to oxidative stress and mitochondria swelling.

Luo N, Yue F, Jia Z, Chen J, Deng Q, Zhao Y, Kuang S.

FASEB J. 2021 Apr;35(4):e21426. doi: 10.1096/fj.202002464R.

PMID: 33749882 

A robust and flexible CRISPR/Cas9-based system for neutrophil-specific gene inactivation in zebrafish.

Wang Y, Hsu AY, Walton EM, Park SJ, Syahirah R, Wang T, Zhou W, Ding C, Lemke AP, Zhang G, Tobin DM, Deng Q.

J Cell Sci. 2021 Apr 15;134(8):jcs258574. doi: 10.1242/jcs.258574. Epub 2021 Apr 22.

PMID: 33722979

Editorial: The Function of Phagocytes in Non-Mammals.

Lu XJ, Deng Q, Thompson KD.

Front Immunol. 2020 Dec 11;11:628847. doi: 10.3389/fimmu.2020.628847. eCollection 2020.

PMID: 33362804 

Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton.

Zhou W, Hsu AY, Wang Y, Syahirah R, Wang T, Jeffries J, Wang X, Mohammad H, Seleem MN, Umulis D, Deng Q.

J Cell Sci. 2020 Sep 4;133(17):jcs248880. doi: 10.1242/jcs.248880.

PMID: 32788232 

Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1-Dependent Functions in Neutrophils.

Cash JN, Chandan NR, Hsu AY, Sharma PV, Deng Q, Smrcka AV, Tesmer JJG.

Mol Pharmacol. 2020 Mar;97(3):226-236. doi: 10.1124/mol.119.117556. Epub 2020 Jan 3.

PMID: 31900312 

Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration.

Hsu AY, Wang D, Liu S, Lu J, Syahirah R, Bennin DA, Huttenlocher A, Umulis DM, Wan J, Deng Q.

Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18561-18570. doi: 10.1073/pnas.1905221116. Epub 2019 Aug 26.

PMID: 31451657

Inducible overexpression of zebrafish microRNA-722 suppresses chemotaxis of human neutrophil like cells.

Hsu AY, Liu S, Syahirah R, Brasseale KA, Wan J, Deng Q.

Mol Immunol. 2019 Aug;112:206-214. doi: 10.1016/j.molimm.2019.06.001. Epub 2019 Jun 5.

PMID: 31176200 

miRNA-223 at the crossroads of inflammation and cancer.

Jeffries J, Zhou W, Hsu AY, Deng Q.

Cancer Lett. 2019 Jun 1;451:136-141. doi: 10.1016/j.canlet.2019.02.051. Epub 2019 Mar 13.

PMID: 30878527 

Development and Characterization of an Endotoxemia Model in Zebra Fish.

Hsu AY, Gurol T, Sobreira TJP, Zhang S, Moore N, Cai C, Zhang ZY, Deng Q.

Front Immunol. 2018 Mar 29;9:607. doi: 10.3389/fimmu.2018.00607. eCollection 2018.

PMID: 29651289 

Neutrophil-specific knockout demonstrates a role for mitochondria in regulating neutrophil motility in zebrafish.

Zhou W, Cao L, Jeffries J, Zhu X, Staiger CJ, Deng Q.

Dis Model Mech. 2018 Mar 28;11(3):dmm033027. doi: 10.1242/dmm.033027.

PMID: 29590639 

MicroRNA-223 Suppresses the Canonical NF-κB Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation.

Zhou W, Pal AS, Hsu AY, Gurol T, Zhu X, Wirbisky-Hershberger SE, Freeman JL, Kasinski AL, Deng Q.

Cell Rep. 2018 Feb 13;22(7):1810-1823. doi: 10.1016/j.celrep.2018.01.058.

PMID: 29444433 

Overexpression of microRNA-722 fine-tunes neutrophilic inflammation by inhibiting Rac2 in zebrafish.

Hsu AY, Wang D, Gurol T, Zhou W, Zhu X, Lu HY, Deng Q.

Dis Model Mech. 2017 Nov 1;10(11):1323-1332. doi: 10.1242/dmm.030791. Epub 2017 Sep 27.

PMID: 28954734 

Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues.

Powell D, Tauzin S, Hind LE, Deng Q, Beebe DJ, Huttenlocher A.

Cell Rep. 2017 May 23;19(8):1572-1585. doi: 10.1016/j.celrep.2017.04.078.

PMID: 28538177 

Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish.

Rosowski EE, Deng Q, Keller NP, Huttenlocher A.

J Immunol. 2016 Dec 15;197(12):4780-4790. doi: 10.4049/jimmunol.1600928. Epub 2016 Nov 11.

PMID: 27837107 

EsxA membrane-permeabilizing activity plays a key role in mycobacterial cytosolic translocation and virulence: effects of single-residue mutations at glutamine 5.

Zhang Q, Wang D, Jiang G, Liu W, Deng Q, Li X, Qian W, Ouellet H, Sun J.

Sci Rep. 2016 Sep 7;6:32618. doi: 10.1038/srep32618.

PMID: 27600772 

MicroRNAs in neutrophils: potential next generation therapeutics for inflammatory ailments.

Gurol T, Zhou W, Deng Q.

Immunol Rev. 2016 Sep;273(1):29-47. doi: 10.1111/imr.12450.

PMID: 27558326 Review.