Publications

Engineering of genetically encoded programmable calcium channel inhibitory binders.

Liu X, Ali S, Lan TH, Wang D, McKee B, Nonomura T, Liu S, Zhao F, Zhu MX, Huang Y, Deng Q, Ma G, Zhou Y.

Nat Commun. 2026 Apr 13;17(1):3472. doi: 10.1038/s41467-026-71769-2.

scChat: A Large Language Model-Powered Co-Pilot for Contextualized Single-Cell RNA Sequencing Analysis.

Chiu HH, Varghese A, Shao K, Lu YC, Nahar R, Chen H, Deng Q, Bao X, Li C.

AIChE J. 2026 Feb 11:e70285. doi: 10.1002/aic.70285. Online ahead of print.

Blood-catalyzed n-doped polymers for reversible optical neural control.

Samal S, Xiao S, Nelson S, Kolhe O, Khan HF, Matin MH, Lee WJ, Ahmed M, Wang D, Wang T, Pikes T, Scott AN, Rodriguez JA, Olson MR, Deng Q, Parkinson EI, Rochet JC, Jayant K, Mei J.

Science. 2026 Apr 2;392(6793):eadu5500. doi: 10.1126/science.adu5500. Epub 2026 Apr 2.

RABEP1 regulates neutrophil migration via endosomal recycling and actin polymerization.

Kim DH, Syahirah R, Zheng C, Ding C, Hsu AY, Pikes T, Liang Z, Liu S, Li L, Bao X, Umulis D, Wan J, Deng Q.

J Leukoc Biol. 2026 Feb 9;118(2):qiaf174. doi: 10.1093/jleuko/qiaf174.

Inwardly rectifying potassium channels promote directional sensing during neutrophil chemotaxis.

Wang T, Kim DH, Ding C, Wang D, Zhang W, Silic M, Cheng X, Shao K, Ku T, Zheng C, Xie J, Xiao S, Jayant K, Yuan C, Chubykin AA, Staiger CJ, Zhang G, Deng Q.

J Cell Biol. 2026 Jan 5;225(1):e202503037. doi: 10.1083/jcb.202503037. Epub 2025 Nov 19.

Rules of life at the interface of calcium signaling and mechanobiology.

Li L, Gazzo D, Saad SM, Larson NJ, Kim ES, Kumar N, Mim MS, Krishnan MJ, Speybroeck B, Ding C, Xiao S, Mullins MC, Iyer-Pascuzzi AS, Deng Q, Pienaar E, Evans JP, Umulis DM, Zartman JJ.

APL Bioeng. 2025 Nov 26;9(4):041504. doi: 10.1063/5.0284022. eCollection 2025 Dec.

Reactive oxygen species counteract zebrafish wound contraction and promote wound healing.

Ding C, Li L, Wang Y, Nguyen HA, Chan DD, Umulis DM, Buganza AT, Deng Q.

Biophys J. 2025 Nov 4;124(21):3717-3732. doi: 10.1016/j.bpj.2025.09.027. Epub 2025 Sep 19.

A Physics-Informed Deep Learning Deformable Medical Image Registration Method Based on Neural ODEs.

Amiri-Hezaveh A, Tan S, Deng Q, Umulis D, Cunniff L, Weickenmeier J, Buganza Tepole A.

Int J Comput Vis. 2025;133(9):6374-6399. doi: 10.1007/s11263-025-02476-6. Epub 2025 Jun 8.

MicroRNA-375 modulates neutrophil chemotaxis via targeting Cathepsin B in zebrafish.

Wang D, Wang T, Kim D, Tan S, Liu S, Wan J, Deng Q.

Fish Shellfish Immunol. 2024 Nov;154:109933. doi: 10.1016/j.fsi.2024.109933. Epub 2024 Sep 28.

Low-cost Polyethylene Terephthalate Lamination Microfluidics Designs for Multiplexed Zebrafish Imaging.

Tan S, Zhu X, Zartman JJ, Deng Q.

J Vis Exp. 2024 Sep 27;(211):10.3791/67313. doi: 10.3791/67313.

Nat Struct Mol Biol. 2024 Aug;31(8):1198-1207. doi: 10.1038/s41594-024-01265-y. Epub 2024 Apr 2.

Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ.

Chen CL, Syahirah R, Ravala SK, Yen YC, Klose T, Deng Q, Tesmer JJG.

Nat Struct Mol Biol. 2024 Apr 2. doi: 10.1038/s41594-024-01265-y.

Atypical peripheral actin band formation via overactivation of RhoA and nonmuscle myosin II in mitofusin 2-deficient cells.

Wang Y, Troughton LD, Xu F, Chatterjee A, Ding C, Zhao H, Cifuentes LP, Wagner RB, Wang T, Tan S, Chen J, Li L, Umulis D, Kuang S, Suter DM, Yuan C, Chan D, Huang F, Oakes PW, Deng Q.

Elife. 2023 Sep 19;12:e88828. doi: 10.7554/eLife.88828.

Engineered hematopoietic and immune cells derived from human pluripotent stem cells.

Chang Y, Hummel SN, Jung J, Jin G, Deng Q, Bao X.

Exp Hematol. 2023 Nov;127:14-27. doi: 10.1016/j.exphem.2023.08.006. Epub 2023 Aug 22.

A Pluripotent Road to Immunoengineering.

Chang Y, Deng Q, Bao X.

Nat Rev Bioeng. 2023 Aug;1(8):541-542. doi: 10.1038/s44222-023-00056-2. Epub 2023 Mar 31.

Method for Visualization of Emergency Granulopoiesis in the Zebrafish Embryo.

Syahirah R, Beckman J, Malik H, Hsu AY, Deng Q.

Zebrafish. 2023 Aug;20(4):175-179. doi: 10.1089/zeb.2023.0014. Epub 2023 Jun 12.

Engineered anti-prostate cancer CAR-neutrophils from human pluripotent stem cells.

Harris JD, Chang Y, Syahirah R, Lian XL, Deng Q, Bao X.

J Immunol Regen Med. 2023 May;20:100074. doi: 10.1016/j.regen.2023.100074. Epub 2023 Apr 1.

CAR-neutrophil mediated delivery of tumor-microenvironment responsive nanodrugs for glioblastoma chemo-immunotherapy.

Chang Y, Cai X, Syahirah R, Yao Y, Xu Y, Jin G, Bhute VJ, Torregrosa-Allen S, Elzey BD, Won YY, Deng Q, Lian XL, Wang X, Eniola-Adefeso O, Bao X.

Nat Commun. 2023 Apr 20;14(1):2266. doi: 10.1038/s41467-023-37872-4.

Chemically defined generation of human definitive hematopoietic stem and progenitor cells.

Jung J, Chang Y, Jin G, Deng Q, Lian XL, Bao X.

STAR Protoc. 2023 Mar 17;4(1):101953. doi: 10.1016/j.xpro.2022.101953. Epub 2022 Dec 16.

Macrophages and neutrophils are necessary for ER stress-induced β cell loss.

Yang B, Yang L, Wang Y, Maddison LA, Tang Z, Haigh S, Gong Y, Zhang Y, Covington BA, Bosma KJ, Tong X, Page-McCaw P, Gannon M, Deng Q, Chen W.

Cell Rep. 2022 Aug 23;40(8):111255. doi: 10.1016/j.celrep.2022.111255.

Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy.

Chang Y, Syahirah R, Wang X, Jin G, Torregrosa-Allen S, Elzey BD, Hummel SN, Wang T, Li C, Lian X, Deng Q, Broxmeyer HE, Bao X.

Cell Rep. 2022 Jul 19;40(3):111128. doi: 10.1016/j.celrep.2022.111128.

Chemically-defined generation of human hemogenic endothelium and definitive hematopoietic progenitor cells.

Chang Y, Syahirah R, Oprescu SN, Wang X, Jung J, Cooper SH, Torregrosa-Allen S, Elzey BD, Hsu AY, Randolph LN, Sun Y, Kuang S, Broxmeyer HE, Deng Q, Lian X, Bao X.

Biomaterials. 2022 Jun;285:121569. doi: 10.1016/j.biomaterials.2022.121569. Epub 2022 May 6.

Rora Regulates Neutrophil Migration and Activation in Zebrafish.

Hsu AY, Wang T, Syahirah R, Liu S, Li K, Zhang W, Wang J, Cao Z, Tian S, Matosevic S, Staiger CJ, Wan J, Deng Q.

Front Immunol. 2022 Mar 4;13:756034. doi: 10.3389/fimmu.2022.756034. eCollection 2022.

A curious case of cyclin-dependent kinases in neutrophils.

Syahirah R, Hsu AY, Deng Q.

J Leukoc Biol. 2022 May;111(5):1057-1068. doi: 10.1002/JLB.2RU1021-573R. Epub 2022 Feb 21.

Mitofusin-2 regulates leukocyte adhesion and β2 integrin activation.

Liu W, Hsu AY, Wang Y, Lin T, Sun H, Pachter JS, Groisman A, Imperioli M, Yungher FW, Hu L, Wang P, Deng Q, Fan Z.

J Leukoc Biol. 2022 Apr;111(4):771-791. doi: 10.1002/JLB.1A0720-471R. Epub 2021 Sep 8.

Reduced electron transport chain complex I protein abundance and function in Mfn2-deficient myogenic progenitors lead to oxidative stress and mitochondria swelling.

Luo N, Yue F, Jia Z, Chen J, Deng Q, Zhao Y, Kuang S.

FASEB J. 2021 Apr;35(4):e21426. doi: 10.1096/fj.202002464R.

A robust and flexible CRISPR/Cas9-based system for neutrophil-specific gene inactivation in zebrafish.

Wang Y, Hsu AY, Walton EM, Park SJ, Syahirah R, Wang T, Zhou W, Ding C, Lemke AP, Zhang G, Tobin DM, Deng Q.

J Cell Sci. 2021 Apr 15;134(8):jcs258574. doi: 10.1242/jcs.258574. Epub 2021 Apr 22.

Editorial: The Function of Phagocytes in Non-Mammals.

Lu XJ, Deng Q, Thompson KD.

Front Immunol. 2020 Dec 11;11:628847. doi: 10.3389/fimmu.2020.628847. eCollection 2020.

Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton.

Zhou W, Hsu AY, Wang Y, Syahirah R, Wang T, Jeffries J, Wang X, Mohammad H, Seleem MN, Umulis D, Deng Q.

J Cell Sci. 2020 Sep 4;133(17):jcs248880. doi: 10.1242/jcs.248880.

Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1-Dependent Functions in Neutrophils.

Cash JN, Chandan NR, Hsu AY, Sharma PV, Deng Q, Smrcka AV, Tesmer JJG.

Mol Pharmacol. 2020 Mar;97(3):226-236. doi: 10.1124/mol.119.117556. Epub 2020 Jan 3.

Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration.

Hsu AY, Wang D, Liu S, Lu J, Syahirah R, Bennin DA, Huttenlocher A, Umulis DM, Wan J, Deng Q.

Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18561-18570. doi: 10.1073/pnas.1905221116. Epub 2019 Aug 26.

Inducible overexpression of zebrafish microRNA-722 suppresses chemotaxis of human neutrophil like cells.

Hsu AY, Liu S, Syahirah R, Brasseale KA, Wan J, Deng Q.

Mol Immunol. 2019 Aug;112:206-214. doi: 10.1016/j.molimm.2019.06.001. Epub 2019 Jun 5.

miRNA-223 at the crossroads of inflammation and cancer.

Jeffries J, Zhou W, Hsu AY, Deng Q.

Cancer Lett. 2019 Jun 1;451:136-141. doi: 10.1016/j.canlet.2019.02.051. Epub 2019 Mar 13.

nox2/cybb Deficiency Affects Zebrafish Retinotectal Connectivity.

Weaver CJ, Terzi A, Roeder H, Gurol T, Deng Q, Leung YF, Suter DM.

J Neurosci. 2018 Jun 27;38(26):5854-5871. doi: 10.1523/JNEUROSCI.1483-16.2018. Epub 2018 May 23.

Development and Characterization of an Endotoxemia Model in Zebra Fish.

Hsu AY, Gurol T, Sobreira TJP, Zhang S, Moore N, Cai C, Zhang ZY, Deng Q.

Front Immunol. 2018 Mar 29;9:607. doi: 10.3389/fimmu.2018.00607. eCollection 2018.

Neutrophil-specific knockout demonstrates a role for mitochondria in regulating neutrophil motility in zebrafish.

Zhou W, Cao L, Jeffries J, Zhu X, Staiger CJ, Deng Q.

Dis Model Mech. 2018 Mar 28;11(3):dmm033027. doi: 10.1242/dmm.033027.

PMID: 29590639 

MicroRNA-223 Suppresses the Canonical NF-κB Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation.

Zhou W, Pal AS, Hsu AY, Gurol T, Zhu X, Wirbisky-Hershberger SE, Freeman JL, Kasinski AL, Deng Q.

Cell Rep. 2018 Feb 13;22(7):1810-1823. doi: 10.1016/j.celrep.2018.01.058.

Overexpression of microRNA-722 fine-tunes neutrophilic inflammation by inhibiting Rac2 in zebrafish.

Hsu AY, Wang D, Gurol T, Zhou W, Zhu X, Lu HY, Deng Q.

Dis Model Mech. 2017 Nov 1;10(11):1323-1332. doi: 10.1242/dmm.030791. Epub 2017 Sep 27.

Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues.

Powell D, Tauzin S, Hind LE, Deng Q, Beebe DJ, Huttenlocher A.

Cell Rep. 2017 May 23;19(8):1572-1585. doi: 10.1016/j.celrep.2017.04.078.

Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish.

Rosowski EE, Deng Q, Keller NP, Huttenlocher A.

J Immunol. 2016 Dec 15;197(12):4780-4790. doi: 10.4049/jimmunol.1600928. Epub 2016 Nov 11.

EsxA membrane-permeabilizing activity plays a key role in mycobacterial cytosolic translocation and virulence: effects of single-residue mutations at glutamine 5.

Zhang Q, Wang D, Jiang G, Liu W, Deng Q, Li X, Qian W, Ouellet H, Sun J.

Sci Rep. 2016 Sep 7;6:32618. doi: 10.1038/srep32618.

MicroRNAs in neutrophils: potential next generation therapeutics for inflammatory ailments.

Gurol T, Zhou W, Deng Q.

Immunol Rev. 2016 Sep;273(1):29-47. doi: 10.1111/imr.12450.